Thermodynamics,
M. Rahmanzadeh Derisi; N. Esfandiari
Abstract
One of the methods to reduce the particle size is the GAS method. In this method, the solute and antisolvent should be dissolved well in a solvent. But the solute is not dissolved in a solvent. The aim of studying this model is to determine the phase equilibrium and thermodynamic conditions of (CO2, ...
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One of the methods to reduce the particle size is the GAS method. In this method, the solute and antisolvent should be dissolved well in a solvent. But the solute is not dissolved in a solvent. The aim of studying this model is to determine the phase equilibrium and thermodynamic conditions of (CO2, solvent, 5-Fluorouracil) in the GAS process. The solvents include methanol, ethanol, acetone, 1-propanol, and 1-butanol. The Peng-Robinson equation of state with a linear combination of Vidal and Michelsen mixing rules (PR-LCVM) was used for the thermodynamic modeling. The volume expansion of the binary system (CO2, solvent) and ternary system (CO2, solvent,5-Fluorouracil) at the temperature range of 313.15-319.15 K was investigated. The Pmin values for the binary system were 66.7, 69.6, 60, 73.7, and 76.8 bar respectively for methanol, ethanol, acetone, 1-propanol, and 1-butanol at 313.15 K,. The Pmin for the ternary system was also calculated. The comparison between the Pmin values of binary and ternary systems showed that for a constant temperature and a certain solvent, the calculated minimum pressure in the ternary system was greater than the same in the binary system
M. Rahmanzadeh derisi; N. Esfandiari
Abstract
The gas antisolvent (GAS) process has been employed for pharmaceutical micronization. Ampicillin was dissolved in organic solvent and carbon dioxide as an antisolvent was injected into this solution, consequently, volume expansion and sharp reduction in liquid solvent power were shown. The particles ...
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The gas antisolvent (GAS) process has been employed for pharmaceutical micronization. Ampicillin was dissolved in organic solvent and carbon dioxide as an antisolvent was injected into this solution, consequently, volume expansion and sharp reduction in liquid solvent power were shown. The particles in GAS process are not seen in any operating conditions. Thermodynamic modeling of GAS can evaluate the operating conditions. In this project, the effect of solvent on optimal thermodynamic conditions of the binary system (CO2, solvent) and ternary system (CO2, solvent, ampicillin) were investigated. The relative change in molar volume in different solvent (ethanol, 1-propanol, 1-butanol, and 1-pentanol) was studied for determination of the optimum operating conditions. The combination of Peng-Robinson EOS and Vidal and Michelsen mixing rule (LCVM) was selected to determine the optimum operating condition of the GAS process. The effect of solvent on minimum pressure was investigated. The calculated Pmin was 70, 70.86, 72.2 and 73.4 bar for ethanol, 1-propanol, 1-butanol, and 1-pantanol at, 308.15 K respectively. According to modeling results, when the molecular weight of the solvent was increased, the value of Pmin was increased.