TY - JOUR ID - 130363 TI - Electrospun Acellular Heart ECM for Cardiac Tissue Engineering JO - Iranian Journal of Chemical Engineering(IJChE) JA - IJCHE LA - en SN - 1735-5397 AU - mashayekhiyan, Sh. AU - Jahanshahi, M. AU - Jafarkhani, M. AU - Entezari, K. AU - Niazi, M. AU - Kabir, H. AD - Uni sharif AD - Department of Chemical and Petroleum Engineering, Sharif University of Technology AD - School of Chemical Engineering, College of Engineering, University of Tehran Y1 - 2021 PY - 2021 VL - 18 IS - 1 SP - 3 EP - 15 KW - Cardiac Tissue Engineering KW - Electrospinning KW - extracellular matrix KW - Poly(vinyl pyrrolidone DO - 10.22034/ijche.2021.130363 N2 -  Electrospun nanofiber is one of the promising alternatives for use in tissue engineering and drug delivery due to its controllable characteristics. However, choosing an appropriate biomaterial for a specific tissue regeneration plays a significant role in fabricating functional tissue-engineered constructs. Heart extracellular matrix (ECM)-derived electrospun nanofiber which mimic the physicochemical and structural characteristics of cardiac tissue is advantageous for cardiac tissue engineering. In this study, acellular calf heart ECM has been investigated as a potential biomaterial to be electrospun in a novel combination with poly vinyl pyrrolidone (PVP), gelatin (Gel) and polycaprolactone (PCL) for cardiac tissue engineering. The obtained fibers were aligned, uniform, and bead free. After fabrication, the scaffolds were cross-linked in glutaraldehyde vapor to become mechanically stronger and dissoluble in the aqueous environments. Considering surface topography, biocompatibility, hydrophilicity, and mechanical properties, the fabricated hybrid electrospun ECM/PVP/Gel/PCL fibers can be proposed as a biomimetic scaffold for heart tissue engineering applications. UR - https://www.ijche.com/article_130363.html L1 - https://www.ijche.com/article_130363_2283faee551352573a30fcc5674378d0.pdf ER -