Effect of Solvent on the Optimal Thermodynamic Conditions of Ternary System (CO2, Alcohol, Ampicillin) in GAS Process


1 Department of Chemical Engineering, South Tehran Branch, Islamic Azad University, Tehran, Iran.

2 Department of Chemical Engineering, Marvdasht Branch, Islamic Azad University, Marvdasht, Iran


The gas antisolvent (GAS) process has been employed for pharma‌ceutical micronization. Ampicillin was dissolved in organic solvent and carbon dioxide as an antisolvent was injected into this solution, consequently, volume expansion and sharp reduction in liquid solvent power were shown. The particles in GAS process are not seen in any operating conditions. Thermodynamic modeling of GAS can evaluate the operating conditions. In this project, the‌ effect of solvent on optimal thermodynamic conditions of the binary system (CO2, solvent) and ternary system (CO2, solvent, ampicillin) were investigated. The relative change in molar volume in different solvent