General Purpose Polystyrene (GPPS) has weak properties and this weakness made the applications of this polymer to be limited. Therefore, the use of mixtures of polymers can improve these properties. Different parameters like mixing speed can affect the quality of the properties of the preparing polymer from mixture of several polymers. In this research, the polymer blend of GPPS and Acrylonitril-Butadiene Styrene (ABS) has been investigated. In order to prepare this polymer mixture, GPPS has been assigned as main phase (base polymer) and ABS has been assigned as scattered phase (additive). Firstly, the blended polymer with different weight percentages (0, 0.04, 0.08 and 0.12) of ABS/GPPS in different mixing speed (30, 40, 50 and 60 rpm) has been prepared and for each mixture, Melt Flow Index (C), Vicat Softening Temperature, Tensile at Break and impact test has been measured. The laboratory data collected from different tests, has been simulated by Multi-Layer Perceptron (MLP) method of Artificial Neural Networks (ANN) and the results of the simulated data covered the laboratory data perfectly. The results declare data the presence of ABS in mixed polymer improved the Tensile strength and thermal properties. In order to reach the highest quality in accomplished tests, it is considered to use ABS in high percentage (0.12) and the maximum possible mixing speed (60rpm).