Biomedical and Biotechnology,
F. Soltani-Tehrani; M. Fattahi; M. Motevassel
Abstract
Drug delivery systems (DDSs) have become a crucial aspect of cancer therapy, and researchers are continuously striving to identify the optimal methods for targeted delivery and release of therapeutic agents. Metal-Organic Frameworks (MOFs) have emerged as a promising class of materials for DDSs due to ...
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Drug delivery systems (DDSs) have become a crucial aspect of cancer therapy, and researchers are continuously striving to identify the optimal methods for targeted delivery and release of therapeutic agents. Metal-Organic Frameworks (MOFs) have emerged as a promising class of materials for DDSs due to their exceptional storage capacity, unique characteristics, and high durability. This comprehensive review explores the wide-ranging applications of MOFs in various fields, including catalysis, gas separation and storage, fuel purification, water treatment, medication administration, and imaging. The review paper evaluates different approaches to synthesize MOFs, such as self-assembly of metal ions and clusters and the solvothermal method, to optimize their performance characteristics.The present study aims to shed light on the numerous challenges associated with utilizing MOFs in clinical settings. However, MOF nanocomposites that incorporate reinforcement phases represents a promising strategy for addressing these issues. With the incidence of cancer on the rise, targeted MOFs offer a potential solution to the lack of selectivity of certain drugs by virtue of their distinctive physical and chemical properties. This investigation delves into how MOFs can be employed to regulate drug release in DDSs and presents research on key applications of MOFs in the realm of cancer therapy. The application of UiO-66 for drug delivery systems and explore the different physical characteristics and chemical structures of dicarboxylate ligands incorporated into UiO-66 topology MOFs were investigated. Overall, the review paper provides a comprehensive overview of the diverse applications of MOFs and their potential for drug delivery systems in cancer therapy.
Reaction Engineering, Kinetics and Catalysts,
A. Payan; M. Fattahi; B. Roozbehani; S. Jorfi
Volume 15, Issue 3 , September 2018, , Pages 3-14
Abstract
The nitrogen doped TiO2 as heterogeneous photocatalyst via sol-gel method were successfully synthesized. The physicochemical, morphological and textural characteristics of the obtained TiO2 samples were characterized by advanced analysis techniques. The photocatalytic activity of the samples were evaluated ...
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The nitrogen doped TiO2 as heterogeneous photocatalyst via sol-gel method were successfully synthesized. The physicochemical, morphological and textural characteristics of the obtained TiO2 samples were characterized by advanced analysis techniques. The photocatalytic activity of the samples were evaluated for degradation of 4-CP under solar irradiation. The as-synthesized photocatalysts were characterized with X-ray diffraction (XRD), surface area measurements (BET and BJH), Fourier transform infrared spectroscopy (FT-IR), field emission scanning electron microscopy (FE-SEM), energy dispersive spectroscopy (EDS) and energy dispersive X-ray spectrum (EDX). The activities of as-prepared TiO2 photocatalysts were examined for the degradation of 4-Chlorophenol aqueous solution under solar irradiation in a photoreactor and photocatalytic degradation mechanism and pathway have been investigated. The results show that the 3% wt. N-doped TiO2 nanoparticles under conditions (solution pH of 4.0, catalyst loading of 2 g/L, initial 4-CP concentration of 10 mg/L, Time of 8 h) exhibits much higher photocatalytic degradation efficiency (91%) as compared with that of 5% wt. N-doped (83%), 1% wt. N-doped (71%), and pure TiO2 (35%).