Biomedical and Biotechnology,
M. Takapoui; M. Saadatmand; F. Ghobadi
Abstract
Numerous bone disorders and injuries, such as osteoporosis, are among the most spreading types of human tissue injuries worldwide, and the available treatments for these injuries are often insufficient and inefficient. Nowadays a lot of attention has been paid to the regenerative medicine, specifically ...
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Numerous bone disorders and injuries, such as osteoporosis, are among the most spreading types of human tissue injuries worldwide, and the available treatments for these injuries are often insufficient and inefficient. Nowadays a lot of attention has been paid to the regenerative medicine, specifically tissue engineering because of its unique features. The extracellular matrix is a key component in tissue engineering because it must have specific properties to support cell survival and proliferation. Natural and synthetic polymeric hydrogels are among the materials commonly employed in tissue engineering. Because the extracellular matrix of bone is particularly mineralized and has a high elasticity, various nanoparticles are commonly utilized to improve the mechanical properties of polymeric hydrogels. In this study, first we extracted the collagen type I from rat tail and characterized it with FTIR spectrum and self-assembly, second we synthesised the bioactive glass nanoparticles and characterized them with XRD and EDAX. Then we developed a polymeric collagen hydrogel (3 mg/ml) scaffold, including bioactive glass nanoparticles (3 %w/v) which increase the mechanical properties of the scaffold (103 pa elastic modulus) in comparison to those of the collagen scaffold (0% w/v nanoparticles), that can be used for bone tissue engineering applications.
Transport Phenomena,
H. Hoorijani; R. Zarghami; N. Mostoufi
Abstract
The effect of adding isopropanol (ISP) to nitrogen as the fluidizing gas on the hydrodynamics of the fluidization of hydrophilic titanium nanoparticles was studied. It was shown by the pressure drop method that adding ISP reduces the minimum fluidization velocity. Wavelet transform of the pressure fluctuations ...
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The effect of adding isopropanol (ISP) to nitrogen as the fluidizing gas on the hydrodynamics of the fluidization of hydrophilic titanium nanoparticles was studied. It was shown by the pressure drop method that adding ISP reduces the minimum fluidization velocity. Wavelet transform of the pressure fluctuations of the bed was employed to identify the hydrodynamic structures. The energy of hydrodynamic structures was evaluated in each fluidization mode. It was shown that ISP reduces the inter-particle attractive forces by replacing the hydroxyl group of the hydrophilic nanoparticles with an alkyl group. Energy and recurrence analyses were used to define the characteristics of fluidization when adding ISP to nitrogen gas. The energy of macro structures increased when using ISP, having indicated a decrease in the number of bubbles and an increase in the bubble size due to the reduction of inter-particle attractive forces. The increase of the white local areas in the recurrence plots also showed the increase of the bubble size. The recurrence quantification analysis showed the increase of the larger-scale phenomena (i.e. bubbles) in the bed.