The optimization of adsorption-based operations requires an accurate model to represent the separation process. In the present study, single-component adsorption data of L-lysine on its imprinted polymer were fitted to Freundlich, Langmuir-type and Jovanovic-type models. L-Lysine imprinted polymer (LLIP) was prepared by free radical solution polymerization. The best estimate of the parameters of these models by regression analysis was obtained. The statistical analysis of results showed that the experimental data fit the Jovanovic-Freundlich mode, better than other models in terms of f value. The best prediction of retention capacity equal to 0.186 mmol lysine per g of LLIP, which is the nearest value to the experimental data, was obtained by applying the Jovanovic model.