Measurement and Correlation of Ibuprofen in Supercritical Carbon Dioxide Using Stryjek and Vera EOS

Mirzajanzadeh, M.; Zabihi, F.; Ardjmand, M.

Measurement and Correlation of Ibuprofen in Supercritical Carbon Dioxide Using Stryjek and Vera EOS

Document Type : Research note

Authors

M. Mirzajanzadeh ¹

F. Zabihi ²

M. Ardjmand ³

¹ Islamic Azad University, Tehran South Branch, Faculty of Graduate Studies, Department of Chemical Engineering, Tehran-Iran.

² Islamic Azad University, Ayatollah Amoli Branch, Department of Chemical Engineering, Amol-Iran

³ Islamic Azad University, Tehran South Branch, Faculty of Graduate Studies, Department of Chemical Engineering, Tehran-Iran

Abstract

Ibuprofen solubility in supercritical carbon dioxide was measured using a dynamic apparatus at a pressure between 80 and 140 bars at three different temperatures, 308.15, 313.15 and 318.15 K. The mole fraction of Ibuprofen in fluid phase was in the range of 0.015 × 10 -3 - 3.261 × 10 -3 at the mentioned operational condition. Modified Mendez-Santiago and Teja equation were used to check the consistency of the experimental data. Results were correlated using the Stryjek and Vera equation of state with the van der Waals 1-parameter (vdW1) and 2-parameters (vdW2) mixing and combining rules. Interaction parameters along with the percentage of the average absolute relative deviation (%AARD) were displayed. Also, the Lydersen group contribution methods were used for predicting the physicochemical and critical properties of the Ibuprofen.

Keywords

Ibuprofen Solubility

Supercritical Carbon Dioxide

Stryjek and Vera EOS

Mendez-Santiago and Teja Equation