Iranian Journal of Chemical Engineering (IJChE)
Scientific Journal

Determining the Optimal Thermodynamic Conditions of Ternary Systems Containing (CO2, Solvent, 5-Fluorouracil) in the GAS Process

Document Type : Regular Article

Authors

M. Rahmanzadeh Derisi 1
N. Esfandiari 2

1 Department of Chemical Engineering, South Tehran Branch, Islamic Azad University, Tehran, Iran.

2 Department of Chemical Engineering, Marvdasht Branch, Islamic Azad University, Marvdasht, Iran

https://doi.org/10.22034/ijche.2022.338671.1431
Abstract
One of the methods to reduce the particle size is the GAS method. In this method, the solute and antisolvent should be dissolved well in a solvent. But the solute is not dissolved in a solvent. The aim of studying this model is to determine the phase equilibrium and thermodynamic conditions of (CO2, solvent, 5-Fluorouracil) in the GAS process. The solvents include methanol, ethanol, acetone, 1-propanol, and 1-butanol. The Peng-Robinson equation of state with a linear combination of Vidal and Michelsen mixing rules (PR-LCVM) was used for the thermodynamic modeling. The volume expansion of the binary system (CO2, solvent) and ternary system (CO2, solvent,5-Fluorouracil) at the temperature range of 313.15-319.15 K was investigated. The Pmin values for the binary system were 66.7, 69.6, 60, 73.7, and 76.8 bar respectively for methanol, ethanol, acetone, 1-propanol, and 1-butanol at 313.15 K,. The Pmin for the ternary system was also calculated. The comparison between the Pmin values of binary and ternary systems showed that for a constant temperature and a certain solvent, the calculated minimum pressure in the ternary system was greater than the same in the binary system

Keywords

GAS Process
Peng-Robinson
LCVM
Optimal Condition
5-Fluorouracil

Subjects

  • References

    • Yoon, T. J., Son, W. S., Park, H. J., Seo, B., Kim, T. and Lee, Y. W., “Tetracycline nanoparticles precipitation using supercritical and liquid CO2 as anti-solvent”, Supercrit. Fluids, 107, 51 (2016).
    • Tsai, C. C., Lin, H. M. and Lee, M. J., “Phase equilibrium and micronization for flufenamic acid with supercritical carbon dioxide”, Taiwan Inst. Chem. Eng., 000, 1 (2017).
    • Fattahi, A., Karimi-Sabet, J., Keshavarz, A., Golzary, A. A., Rafiee-Tehrani, M. and Dorkoosh, F. A., “Preparation and characterization of simvastatin nanoparticles using rapid expansion of supercritical solution (RESS) with trifluoromethane”, Supercrit. Fluid, 170, 469 (2016).
    • Esfandiari, N. and Sajadian, S. A., “CO2 utilization as gas antisolvent for the pharmaceutical micro and nanoparticle production: A review”, Arabian J. Chem., 15, 104164 (2022).
    • Ghoreishi, S. M., Hedayat, A. and Kordnejad, M., “Micronization of chitosan via rapid expansion of supercritical solution”, Supercrit. Fluid, 111, 162 (2016).
    • Esfandiari, N., “Production of micro and nanoparticles of pharmaceutical by supercritical carbon dioxide”, Supercrit. Fluid, 100, 129 (2015).
    • Mendes, M. F., Uller, A. M. C. and Pessoa, F. L. P., “Simulation and thermodynamic modeling of the extraction of tocopherol from a synthetic mixture of tocopherol, squalene, and CO2”, Chem. Eng., 17, 761 (2000).
    • Spiliotis, N., Magoulas, K. and Tassios, D., “Prediction of the solubility of aromatic hydrocarbons in supercritical CO2 with EOS/GE models”, Fluid Phase Equilib., 102, 121 (1999).
    • Zhang, Q., Yan, X., Zheng, P. and Wang, Z., “Influence factors on activity of Ru–Zn catalysts in selective hydrogenation of benzene”, Chinese J. Chem. Eng., 25, 294 (2017).
    • Gerszt, R., Pessoa, F. L. P. and Mendes, M. F., “Phase behavior of sterols and vitamins in supercritical CO2”, J. Chem. Eng., 17, 261 (2000).
    • Najafi, M., Esfandiari, N., Honarvar, B. and Arab Aboosadi, Z., “Thermodynamic modeling of the gas-anti solvent (GAS) process for precipitation of finasteride”, Chem. Petrol. Eng., 54, 297 (2020).
    • Sajadian, S. A., Ardestani, N. S., Esfandiari, N. and Jouyban, A., “Solubility of favipiravir (as an anti-COVID-19) in supercritical carbon dioxide: An experimental analysis and thermodynamic modeling”, Supercrit. Fluid., 183, 105539 (2022).
    • Esfandiari, and Sajadian, S. A., “Experimental and modeling investigation of glibenclamide solubility in supercritical carbon dioxide”, Fluid Phase Equilib., 556, 113408 (2022).
    • Esfandiari, N. and Ghoreishi, S. M., “Optimal thermodynamic conditions for ternary system (CO2, DMSO, ampicillin) in supercritical CO2 anti solvent process”, Chem. Eng.,. 502, 31 (2015).
    • Liu, Z., Wang, J., Song, L., Yang, G. and Han, B., “Study on the phase behavior of cholesterol–acetone–CO2 system and crystallization of cholesterol by anti-solvent CO2”, Supercrit. Fluid., 24, 1 (2002).
    • Tombokan, X. C., Aguda, R. M., Danehower, D. A., Kilpatrick, P. K. and Carbonell, R. G., “Three-component phase behavior of the sclareol-ethyl lactate-carbon dioxide system for GAS applications”, Supercrit. Fluid., 45, 146 (2008).
    • Paviani, L. C., Chiari, M. R. S., Crespo, T. R. and Cabral, F. A., “Thermodynamic modeling of phase equilibrium behavior of curcumin-CO2-ethanol”, Proceedings of III Iberoamerican Conference on Supercritical Fluids, Cartagena de Indias, Colombia, (2013).
    • de la Fuente, J. C., Shariati, A. and Peters, C. J., “On the selection of optimum thermodynamic conditions for the GAS process”, J. Supercrit., 32, 55 (2004).
    • Walas, S. M., Phase equilibria in chemical engineering, 1st, Butterworth-Heinemann, Boston, (1985).
    • Rahmanzadeh Derisi, M. and Esfandiari, N., “Effect of solvents on the optimal thermodynamic conditions of ternary system (CO2, Alcohol, Ampicillin) in GAS Process”, Iranian J. Chem. Eng., 17, 37 (2020).
    • Mukhopadhyay, M., “Partial molar volume reduction of solvent for solute crystallization using carbon dioxide as anti-solvent”, Supercrit. Fluids., 25, 213 (2003).
    • Yazdanshenas, R. and Gharib, F., “Solubility and thermodynamic functions measurement of morin hydrate in different alcohols”, Mol. Liq., 233, 9 (2017).
    • Boroujeni, H. C. and Gharib, F., “Solubility and thermodynamic functions of deferasirox in different solvents”, Mol. Liq., 219, 350 (2016).
    • Mehl, A., Nascimento, F. P., Falcão, P. W., Pessoa, F. L. P. and Cardozo-Filho, L., “Vapor-liquid equilibrium of carbon dioxide + ethanol: Experimental measurements with acoustic method and thermodynamic modeling”, Thermodyn., 2011, 1 (2011).
    • Joung, S. N., Yoo, C. W., Shin, H. Y., Kim, S. Y., Yoo, K. -P., Lee, C. S. and Huh, W. S., “Measurements and correlation of high-pressure VLE of binary CO2–alcohol systems (methanol, ethanol, 2-methoxyethanol and 2-ethoxyethanol)”, Fluid Phase Equilib., 185, 219 (2001).
    • Kariznovi, M., Nourozieh, H. and Abedi, J., “Experimental measurements and predictions of density, viscosity, and carbon dioxide solubility in methanol, ethanol, and 1-propanol”, Chem. Thermodynamics, 57, 408 (2013).
Iranian Journal of Chemical Engineering (IJChE)
Volume 19, Issue 1
Winter 2022
Pages 3-14

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